发明名称 |
Non-peptidyl moiety-conjugated CD4-gamma2 and CD4 -IgG2 immunoconjugates, and uses thereof |
摘要 |
This invention provides an immunoconjugate which comprises 1) a non-peptidyl toxin and 2) a CD4-gamma2 chimeric heavy chain homodimer linked thereto. This invention also provides an immunoconjugate which comprises 1) a gamma radiation-emitting radionuclide of low to moderate cytotoxicity and 2) a CD4-gamma2 chimeric heavy chain homodimer linked thereto. This invention further provides an immunoconjugate which comprises 1) a non-peptidyl toxin and 2) a heterotetramer comprising two heavy chains and two light chains, both heavy chains being either a) IgG2 heavy chains or b) chimeric CD4-IgG2 heavy chains, and both light chains being either a) kappa light chains or b) chimeric CD4-kappa light chains. This invention further provides an immunoconjugate which comprises 1) a gamma radiation-emitting radionuclide of low to moderate cytotoxicity and 2) a heterotetramer comprising two heavy chains and two light chains, both heavy chains being either a) IgG2 heavy chains or b) chimeric CD4-IgG2 heavy chains, and both light chains being either a) kappa light chains or b) chimeric CD4-kappa light chains. Finally, this invention provides methods of using the immunoconjugates of the subject invention.
|
申请公布号 |
US2002052481(A1) |
申请公布日期 |
2002.05.02 |
申请号 |
US20010766995 |
申请日期 |
2001.01.22 |
申请人 |
PROGENICS PHARMACUETICALS, INC. |
发明人 |
MADDON PAUL J.;ALLAWAY GRAHAM P. |
分类号 |
G01N33/569;A61K38/00;A61K39/21;A61K39/385;A61K39/395;A61K39/40;A61K39/42;A61K39/44;A61K47/48;A61K51/00;A61K51/10;A61M36/14;A61P31/12;C07K14/73;C07K16/00;C07K16/46;C07K17/00;C12N5/10;C12N15/09;C12N15/74;C12P21/02;C12P21/04;C12P21/08;(IPC1-7):A61K51/00 |
主分类号 |
G01N33/569 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|