Assay

摘要

A method for identification of a compound that modulates GPR 17 activity comprises contacting a GPR 17 polypeptide with a test compound; and monitoring for cysteinyl leukotriene-receptor activity. The GPR 17 polypeptide has the amino acid sequence of SEQ ID NO: 2; or is a variant thereof which is capable binding a leukotriene such as LTD4, LTE4, LTC4 or LTF4. It can thereby be determined whether the test substance is a modulator of GPR 17 activity.