发明名称 |
MODULATING ANGIOGENESIS |
摘要 |
The invention provides methods and compositions relating to Kuz involvement in angiogenesis. In various embodiments, the invention provides methods for modulating angiogenesis by specifically modulating the activity of Kuz in a vertebrate animal predetermined to have a pathogenic angiogenesis; methods for modulating angiogenesis by specially modulating the activity of Kuz in a vertebrate animal and subsequently detecting a resultant angiogenic modulation in the animal; methods for specifically detecting Kuz activity in a vertebrate animal predetermined to have a pathogenic angiogenesis; methods for specifically detecting a pathogenic angiogenesis in a vertebrate animal having a predetermined Kuz activity; and method for identifying a modulator of angiogenesis by (a) contacting an angiogenic assay system comprising a predetermined amount of Kuz with a candidate agent, under conditions whereby but for the presence of the agent, the system provides a reference angiogenesis; and (b) detecting an agent-biased angiogenesis of the system. |
申请公布号 |
WO0234289(A1) |
申请公布日期 |
2002.05.02 |
申请号 |
WO2001US45612 |
申请日期 |
2001.10.25 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
PAN, DUOJIA;RUBIN, GERALD, M.;ZHANG, HONGBING |
分类号 |
G01N33/48;A61K31/198;A61K31/381;A61K31/405;A61K38/48;A61K39/395;A61K45/00;A61P35/00;A61P43/00;C07K16/18;C12Q1/37;G01N33/53;G01N33/573;G01N33/574;(IPC1-7):A61K39/00;A61K49/00;C12Q1/00 |
主分类号 |
G01N33/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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