发明名称 |
IDENTIFICATION OF A HUMAN CYTOMEGALOVIRUS GENE INVOLVED IN DOWN-REGULATION OF MHC CLASS I HEAVY CHAIN EXPRESSION |
摘要 |
<p>Infection of human fibroblast cells with human cytomegalovirus (HCMV) causes down-regulation of cell surface expression of MHC class I. A recombinant mutant HCMV which fails to down-regulate class I heavy chain expression is described. A method of controlling down-regulation of MHC class I expression in a cytomegalovirus infected cell, a pharmaceutical composition, a vaccine composition, a method of preventing or reducing susceptibility to acute cytomegalovirus in an individual, and a virus based gene therapy vector are also described.</p> |
申请公布号 |
CA2196207(C) |
申请公布日期 |
2002.04.30 |
申请号 |
CA19952196207 |
申请日期 |
1995.07.31 |
申请人 |
AMERICAN CYANAMID COMPANY |
发明人 |
JONES, THOMAS R. |
分类号 |
C12N15/00;A61K31/70;A61K35/76;A61K38/00;A61K39/245;A61K48/00;A61P31/12;C07K14/045;C12N7/00;C12N7/01;C12N7/04;C12N15/01;C12N15/09;C12N15/34;C12N15/38;C12N15/86;C12N15/861;C12R1/92;(IPC1-7):C12N7/01 |
主分类号 |
C12N15/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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