发明名称 |
Taxane prodrugs |
摘要 |
The present invention generally provides taxane prodrugs comprising at least one taxane joined by hydrolyzable bond(s) to one or more polyethylene glycol oligomer(s) selected from the group consisting of a straight or branched polyethylene glycol oligomer having from 1 to 25 polyethylene glycol units and optionally comprising a salt-forming moiety. The polyethylene glycol oligomer preferably comprises a salt-forming moiety, which is preferably selected from the group consisting of ammonium and carboxylate.
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申请公布号 |
US6380405(B1) |
申请公布日期 |
2002.04.30 |
申请号 |
US19990476974 |
申请日期 |
1999.12.31 |
申请人 |
NOBEX CORPORATION |
发明人 |
EKWURIBE NNOCHIRI;BARTLEY GARY S.;PRICE CHRISTOPHER H. |
分类号 |
A61K9/08;A61K9/10;A61K9/14;A61K9/20;A61K9/48;A61K31/337;A61K33/24;A61K45/06;A61K47/48;A61P13/12;A61P33/06;A61P35/00;A61P35/02;A61P43/00;(IPC1-7):C07D305/14 |
主分类号 |
A61K9/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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