CRYSTALLINE R-(R*,R*))-2-(4-FLUOROPHENYL)-BETA,DELTA-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4- (PHENYLAMINO)CARBONYL)-1H-PYRROLE-1-HEPTANOIC ACID HEMI CALCIUM SALT (ATORVASTATIN)

摘要

There are described novel crystalline forms of ÄR-(R*,R*)Ü-2-(4-fluorophenyl)- beta , delta -dihydroxy-5-(1-methylethyl)-3-phenyl-4-Ä(phenylamino)carbonylÜ-1H-pyr role-l-heptanoic acid hemi calcium salt designated Form II and Form IV which are characterized by their X-ray powder diffraction and/or solid state NMR, as well as methods for the preparation and pharmaceutical composition of the same, which are useful as agents for treating hyperlipidemia and hypercholesterolemia.