| 摘要 |
Bis-thiazolyl amine derivatives (I) are new. Bis-thiazolyl amine derivatives of formula (I) are new. [Image] A : a covalent bond or a group of formula (i)-(iii): R : H, OMe, Cl, Br, F, NO2 or CN; n : 1-4; X : H, Br, Me, NO2, CN or NR1R2; Ar1optionally substituted phenyl or optionally substituted 5- or 6-membered heterocyclyl containing one or more heteroatoms selected from N, O and S; and R1, R2H or 1-4C alkyl, branched or cyclic, optionally containing O or N. [Image] ACTIVITY : Cytostatic; antiproliferative; antipsoriatic; antirheumatic; antiarthritic; ophthalmological MECHANISM OF ACTION : Membrane-associated tyrosine and threonine kinase (myt1 kinase) inhibitor; myt1 receptor antagonist. No data given. |
