| 摘要 |
This invention relates to the field of medical technology, more particularly to an antifungal triazole compound with substituted propyl, its salts, and preparation methods thereof. The general formulae of the antifungal substituted propyl triazole (I) and its salts (II) are as shown. Wherein: X is selected from hydrogen or alkyl group; M is hydrogen, hydroxy or ester group; Ar is selected from phenyl, naphthyl, thienyl, furyl, pyridyl and pyrimidinyl substituted by halogen, nitro group, trifluoromethyl or trifluoromethoxy group; the halogen is F, Cl, Br, or I. L is hydrochloric acid, hydrobromic acid methyl sulfonic acid, nitric acid, sufuric acid phosphoric acid, acetic acid, oxalic acid, maleic acid, citric acid, fumaric acid, gluconic acid, lactic acid, maleic acid, succinic acid, tartaric acid, malic acid, especially hydrochloric acid, fumaric acid, gluconic acid, lactic acid and methyl sulfonic acid. Y is (a) Wherein: R1 SIMILAR 8 is selected from hydrogen, alkyl, cyano, or ester group. The alkyl group is selected from C1 SIMILAR C4 chain or branched alkyl group, e.g. methyl, ethyl, n-propyl, iso-propyl, n-butyl, iso- butyl, sec- butyl, tert- butyl. The first choice is methyl, ethyl, cyano, or ester group; R1 SIMILAR 8R1 can also be one or two carbonyl group. Z is selected from N or CH. R is selected from: (1) formacyl; (2) alkyl group; (3) benzyl or substituted benzyl group; (4) Phenyl or substituted phenyl groups. The substituted propyl triazole compounds and their salts of the invention have a wide-spectrum, low toxicity and potent activity against systemic fungal infections. These compounds and their salts can be used to prepare the drugs for the treatment of deep fungal infections. |
