Cells, liposomes and lipid particles are provided with complementary projecting oligonucleotides, which hybridize to bring them together as an aid to efficient fusion, which may be further aided by osmotic or electrical shock. The invention further provides complementary pairs of oligonucleotides containing moieties to anchor them in cellular and liposome membranes, as well as liposomes that carry agents to be introduced into cells and that are provided with membrane-bound projecting oligonucleotides.
申请公布号
WO0233045(A2)
申请公布日期
2002.04.25
申请号
WO2001US42658
申请日期
2001.10.11
申请人
THE PUBLIC HEALTH RESEARCH INSTITUTE OF THE CITY OF NEW YORK, INC.;TYAGI, SANJAY;KRAMER, FRED, R.;ALSMADI, OSAMA, A.