ORAL FORMULATION COMPRISING AN INHIBITOR COMPOUND OF THE ILEAL BILE TRANSPORT AND AN HMG CO-A REDUCTASE INHIBITOR
摘要
An oral pharmaceutical formulation comprising an inhibitor compound of the ileal bile acid transport (IBAT inhibitor), an HMG Co-A reductase inhibitor and a therapeutically acceptable carrier characterised in that the formulation is designed to deliver the IBAT inhibitor in the ileum and the HBG Co A reducetase inhibitor non-specifically into the GI tract. The IBAT inhibitor compound and the HMG Co-A reductase inhibitor can also be administered in combination with a bile acid binder to alleviate possible side effects of therapy with IBAT inhibitor compounds, such as for instance diarrhoea. The bile acid binder may be formulated for colon release.
申请公布号
WO0232428(A1)
申请公布日期
2002.04.25
申请号
WO2001GB04525
申请日期
2001.10.12
申请人
ASTRAZENECA AB;ASTRAZENECA UK LIMITED;STARKE, INGEMAR;ABRAHAMSSON, BERTIL;UNGELL, ANNA-LENA;LINDQVIST, ANN-MARGRET