发明名称 |
METHODS FOR MODULATING BLADDER FUNCTION |
摘要 |
This invention provides methods and pharmaceutical compositions for maintaining bladder control or treating urinary incontinence in a mammal utilizing agonists of KCNQ potassium channels, including KCNQ2, KCNQ3, KCNQ4 and KCNQ5 potassium channels, alone or in combination. Compounds useful in these methods include the 1,2,4-triamino-benzene derivatives described in U.S. Patent No. 5,384,330 (Dieter et al.) and the substituted 3-phenyl oxindole compounds described in U.S. Patent No. 5,565,483 (Hewawasam et al.). Among the preferred compounds of this invention is N-[2-amino-4-(4-fluorobenzylamino)-phenyl]carbamic acid ethyl ester, also referred to as retigabine. |
申请公布号 |
WO0232419(A2) |
申请公布日期 |
2002.04.25 |
申请号 |
WO2001US32204 |
申请日期 |
2001.10.16 |
申请人 |
AMERICAN HOME PRODUCTS CORPORATION |
发明人 |
ARGENTIERI, THOMAS, MICHAEL;SHELDON, JEFFREY, HOWARD;BOWLBY, MARK, ROBERT |
分类号 |
A61K45/00;A61K31/00;A61K31/137;A61K31/17;A61K31/24;A61K31/27;A61K31/404;A61K31/405;A61P13/00;A61P13/02;A61P13/08;A61P13/10;A61P43/00;C07D209/34;C12N5/071;C12N15/09;C12Q1/02;G01N33/15;G01N33/483;G01N33/50;G01N33/68 |
主分类号 |
A61K45/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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