| 发明名称 |
HUMAN GENE CRITICAL TO FERTILITY |
| 摘要 |
Disclosed herein are novel nucleic acid and protein sequences that are essential to fertility. In particular, human <i>Mater</i> cDNA and protein sequences are provided. Functional MATER is required for female fertility; zygotes that arise from <i>Mater</i> null oocytes do not progress beyond the two-cell stage. Methods are described for using <i>Mater</i> molecules in diagnoses, prognosis, and treatment of fertility and reduced fertility. Also provided are methods for using MATER as a contraceptive agent. The disclosure also describes compounds involved in such methods, and the identification of such compounds.
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| 申请公布号 |
WO0232955(A1) |
申请公布日期 |
2002.04.25 |
| 申请号 |
WO2001US10981 |
申请日期 |
2001.04.04 |
| 申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH & HUMAN SERVICES, THE NATIONAL INSTITUTES OF HEALTH;NELSON, LAWRENCE, M.;TONG, ZHI-BIN |
发明人 |
NELSON, LAWRENCE, M.;TONG, ZHI-BIN |
| 分类号 |
A01K67/027;A61K31/711;A61K45/00;A61K48/00;A61P5/24;A61P15/00;A61P15/18;C07H21/04;C07K14/47;C07K16/18;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12N15/12;C12Q1/68;G01N33/15;G01N33/50;G01N33/53;G01N33/564;G01N33/566;(IPC1-7):C07K14/47;C12N15/11;C12N5/06;A61K38/17 |
主分类号 |
A01K67/027 |
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