发明名称 |
ORAL FORMULATION COMPRISING AN INHIBITOR COMPOUND OF THE ILEAL BILE TRANSPORT AND AN HMG CO-A REDUCTASE INHIBITOR |
摘要 |
An oral pharmaceutical formulation comprising an inhibitor compound of the ileal bile acid transport (IBAT inhibitor), an HMG Co-A reductase inhibitor and a therapeutically acceptable carrier characterised in that the formulati on is designed to deliver the IBAT inhibitor in the ileum and the HBG Co A reducetase inhibitor non-specifically into the GI tract. The IBAT inhibitor compound and the HMG Co-A reductase inhibitor can also be administered in combination with a bile acid binder to alleviate possible side effects of therapy with IBAT inhibitor compounds, such as for instance diarrhoea. The bile acid binder may be formulated for colon release.
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申请公布号 |
CA2425831(A1) |
申请公布日期 |
2002.04.25 |
申请号 |
CA20012425831 |
申请日期 |
2001.10.12 |
申请人 |
ASTRAZENECA AB |
发明人 |
STARKE, INGEMAR;LINDQVIST, ANN-MARGRET;UNGELL, ANNA-LENA;ABRAHAMSSON, BERTIL |
分类号 |
A61K9/22;A61K9/14;A61K9/50;A61K31/00;A61K31/40;A61K31/505;A61K31/554;A61K45/00;A61K45/06;A61K47/30;A61P1/12;A61P3/06;(IPC1-7):A61K31/505 |
主分类号 |
A61K9/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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