| 发明名称 |
RECOMBINANT ANTIBODY FRAGMENTS AS AUTOANTIBODY ANTAGONISTS |
| 摘要 |
The invention provides methods and compositions for inhibiting autoantibody binding in demyelinating disease such as multiple sclerosis. The composition s comprise immunoglobulin CDR3 sequences derived from combinatorial phage display libraries selected for high-affinity binding to myelin oligodendrocy te glycoprotein.
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| 申请公布号 |
CA2423073(A1) |
申请公布日期 |
2002.04.25 |
| 申请号 |
CA20012423073 |
申请日期 |
2001.10.17 |
| 申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
VON BUDINGEN, HANS-CHRISTIAN;HAUSER, STEPHEN;GENAIN, CLAUDE |
| 分类号 |
A61K38/00;A61P25/00;A61P37/02;C07K16/18;(IPC1-7):C07K16/18;C07K16/28;A61K39/395 |
主分类号 |
A61K38/00 |
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