| 发明名称 |
DNA MUTAGENESIS BY RANDOM FRAGMENTATION AND REASSEMBLY |
| 摘要 |
<p>The present invention provides methods of evolving a polynucleotide sequence for acquisition of a desired property starting from a population of variants of the polynucleotide. In one embodiment, repeated cycles of recombination and selection permit the directed molecular evolution in vitro or in vivo of an encoded protein.</p> |
| 申请公布号 |
EP0752008(B1) |
申请公布日期 |
2002.04.24 |
| 申请号 |
EP19950911826 |
申请日期 |
1995.02.17 |
| 申请人 |
MAXYGEN, INC. |
发明人 |
STEMMER, WILLEM P.C.;CRAMERI, ANDREAS |
| 分类号 |
C12N15/09;A61K38/00;A61K39/395;C07K14/435;C07K14/545;C07K16/00;C12N9/38;C12N9/86;C12N15/00;C12N15/10;C12P21/08;C12Q1/68;C40B40/02;G01N33/53;G01N33/566;(IPC1-7):C12N15/10 |
主分类号 |
C12N15/09 |
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