发明名称 |
Sustained-release preparation |
摘要 |
According to a first embodiment, there is provided a sustained-release preparation comprising a water-insoluble or slightly water-soluble polyvalent metal salt of a water-soluble physiologically active substance which is not an endothelin antagonist, and a biodegradable polymer. The sustained-release preparation of the first embodiment is highly efficient in incorporating the water-soluble physiologically active substance and suppresses the initial burst of the water-soluble physiologically active substance. The sustained-release preparation of the present invention is capable of releasing the water-soluble physiologically active substance while retaining its bioactivity after administration in vivo. Furthermore, the water-soluble physiologically active substance in the sustained-release preparation is kept stable for a long period of time, with little loss of bioactivity. According to a second embodiment, there is provided a sustained-release preparation comprising an anti-endothelin substance and a biodegradable polymer. The sustained-release preparation of the present invention sustainedly releases an anti-endothelin substance, serving well in the treatment of endothelin-associated diseases.
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申请公布号 |
US6376461(B1) |
申请公布日期 |
2002.04.23 |
申请号 |
US19990426716 |
申请日期 |
1999.10.26 |
申请人 |
TAKEDA CHEMICAL INDUSTRIES, LTD. |
发明人 |
IGARI YASUTAKA;YAMAGATA YUTAKA;IINUMA SATOSHI;OKADA HIROAKI;YAMAMOTO KAZUMICHI |
分类号 |
A01N37/18;A61K9/14;A61K38/18;A61K38/19;A61K38/21;A61K38/22;(IPC1-7):A01N37/18 |
主分类号 |
A01N37/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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