发明名称 |
Kainate-binding, human CNS receptors of the EAA4 family |
摘要 |
Neurotransmission by excitatory amino acids (EAAs) such as glutamate is mediated via membrane-bound surface receptors. DNA coding for one family of these receptors of the kainate-binding type of EAA receptors, has now been isolated and the receptor protein characterized. Herein described are recombinant cell lines which produce the EAA receptor as a heterologous membrane-bound product. Also described are related aspects of the invention, which are of commercial significance. Included is use of the cell lines as a tool for discovery of compounds which modulate EAA receptor stimulation.
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申请公布号 |
US6376200(B1) |
申请公布日期 |
2002.04.23 |
申请号 |
US19940249241 |
申请日期 |
1994.05.25 |
申请人 |
NPS ALLEIX CORP. |
发明人 |
KAMBOJ RAJENDER;ELLIOTT CANDACE E.;NUTT STEPHEN L. |
分类号 |
C07K14/00;C07K14/705;C12N5/10;C12N15/09;C12N15/12;C12P21/02;C12P21/08;C12R1/91;G01N33/53;(IPC1-7):G01N33/567 |
主分类号 |
C07K14/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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