METHOD FOR PRODUCING 6-O-SUBSTITUTED KETOLIDE DERIVATIVE AND ITS INTERMEDIATE

摘要

PROBLEM TO BE SOLVED: To provide a production method useful for efficient synthesis of a 6-O-substituted ketolide derivative of erythromycin A. SOLUTION: An intermediate having a specific ketal group as a protective group of an oxime at the 9-position of 9-oxime of the erythromycin A, and a propionyl group as a protective group for hydroxy groups at 2'-position and 4"-position, is used in the production method.