| 摘要 |
The present invention is directed to polymeric-prodrug transport forms of the formula:wherein:G is a linear or branched, terminally functionalized polymer residue;Y1 is O, S, or NR1;M is X or Q;wherein X is an electron withdrawing group and Q is a moiety containing a free electron pair positioned three to six atoms from C(=Y1);R1-5 are independently selected from the group consisting of hydrogen, C1-6 alkyls, C3-12 branched alkyls, C3-8 cycloalkyls, C1-6 substituted alkyls, C3-8 substituted cycloalkyls, aryls, substituted aryls, aralkyls, C1-6 heteroalkyls, substituted C1-6 heteroalkyls;R6 is OR7 or N3, NH2, NO2 or CN, where R7 is selected from the same group which defines R1-5;R8-9 are independently selected from the group consisting of hydrogen, fluoro, chloro, bromo, iodo, or R6; anda and n are each independently zero or a positive integer.Methods of forming and methods of treating using the polymeric-prodrug transport forms disclosed herein are also disclosed.
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