发明名称 |
Process for the preparation of (4R,6S)-4-hydroxy-6-hydroxymethyl-tetrahydropyran-2-one |
摘要 |
The present invention relates to an improved, efficient and enantio-selective process for the synthesis of (4R, 6S)-4-hydroxy-6-hydroxymethyl tetrahydropyran-2-one, employing the Sharpless asymmetric dihydroxylation and regiospecific nucleophilic hydride opening of the cyclic sulfite/sulfate as the key steps. The invention also resides in the intermediates used in the process.
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申请公布号 |
US6376683(B1) |
申请公布日期 |
2002.04.23 |
申请号 |
US20010872849 |
申请日期 |
2001.06.01 |
申请人 |
COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH |
发明人 |
KUMAR PRADEEP;FERNANDES RODNEY AGUSTINHO |
分类号 |
C07D309/30;(IPC1-7):C07D309/30;C07D317/00 |
主分类号 |
C07D309/30 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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