IMPROVEMENTS IN DETECTION SYSTEMS AND METHODS FOR PREDICTINGTHE DISSOLUTION CURVE OF A DRUG FROM A PHARMACEUTICAL DOSAGE FORM

摘要

The present invention relates to an improvement in a detection system used f or continuously measuring the release of a drug from a pharmaceutical dosage fo rm comprising a singular dissolution vessel or multiple dissolution vessels containing a dissolution medium and a measuring device for detecting the amount of drug released at a given time, the improvement comprising a mixing shaft and a probe placed within the mixing shaft or outside the individual dissolution vessels, the probe capable of measuring the dissolution characteristics using UV, IR, near-IR, fluorescence, electrochemical, and Raman spectroscopy techniques. The present invention also relates to a metho d for predicting the dissolution curve provided by a controlled release pharmaceutical dosage form comprising taking continuous measurements of the amount of drug released from a dosage form for a portion of the time over which the drug is expected to be released and predicting the remainder of th e dissolution curve based on the values obtained.