PEPTIDE (VARIANTS) AND METHOD OF ITS PRODUCTION, PHARMACEUTICAL AGENT, ANTIBODY AND METHOD OF ITS PRODUCTION

摘要

immunology, biotechnology, peptides, pharmacy. SUBSTANCE: peptide shows the following amino acid sequence: ELDKWAS, LELDKWAS, ELDNWAS, ELNKWAS, LELDNWAS or LELNKWAS and promotes to the formation of antibodies. Peptide can be bound with a carrier as virus or viral protein. Peptide bound with a carrier is prepared by recombinant method. Antibody with HIV-1-neutralizing activity and secreted by mucosa envelope surface is prepared by immunization of human or animal. Invention ensures to develop a pharmaceutical agent promoting to the formation of antibodies to strains HIV-1 and/or clinical isolates. Invention can be used for preparing neutralizing antibodies raised to different strains and clinical isolates of HIV-1. EFFECT: improved method of peptide and antibody production. 17 cl, 9 dwg, 1 tbl, 7 ex