发明名称 |
BENZIMIDAZOLE COMPOUNDS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF |
摘要 |
Compounds represented by the following general formula (I) or salts thereof, which show: (1) excellent antiulcer, gastric acid secretion inhibitory, mucosa-protecting and anti<i>-Helicobacter pyroli</i> effects <i>in vivo</i>; (2) a low toxicity; (3) a high stability to acid (i.e., making it unnecessary to process into enteric preparations, thereby saving the cost and facilitating the intake by patients with dysplagia because of the small size); (4) a higher absorption speed than enteric preparations (i.e., achieving higher expression of the gastric acid secretion inhibitory effect); and (5) a long-lasting effect. In said formula, each symbol is as defined in the description. Thus benzimidazole compounds, which are highly stable to acid and can be converted into proton pump inhibitors <i>in vivo</i> to thereby exert an antiulcer effect, etc., can be provided.
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申请公布号 |
WO0230920(A1) |
申请公布日期 |
2002.04.18 |
申请号 |
WO2001JP08943 |
申请日期 |
2001.10.11 |
申请人 |
TAKEDA CHEMICAL INDUSTRIES, LTD.;KAMIYAMA, KEIJI;SATO, FUMIHIKO |
发明人 |
KAMIYAMA, KEIJI;SATO, FUMIHIKO |
分类号 |
A61P1/04;A61P31/04;A61P35/00;C07D401/12;(IPC1-7):C07D401/12;A61K31/443 |
主分类号 |
A61P1/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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