COMPOSITIONS AND METHODS FOR ENHANCING PARACELLULAR PERMEABILITY ACROSS EPITHELIAL AND ENDOTHELIAL BARRIERS
摘要
Compositions and methods for enhancing paracellular permeability at an absorption site in a subject are disclosed. The method includes: (a) administering an effective amount of a phospholipase C inhibitor to a subject at a time in which enhanced paracellular permeability is desired; and (b) enhancing paracellular permaeability in the subject at the the absorption site through the administering of the effective amount of the phospholipase C inhibitor. The disclosed compositions and methods provide enhanced absorption of a hydrophilic drug in a subject.
申请公布号
WO0230408(A2)
申请公布日期
2002.04.18
申请号
WO2001US31501
申请日期
2001.10.10
申请人
UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL;THAKKER, DHIREN, R.;WARD, PETER, D.