摘要 |
A flowable composition for use as a controlled release implant, comprising a biodegradable thermoplastic polyester that is at least substantially insoluble in aqueous medium or body fluid, a biocompatible polar aprotic solvent, miscible to dispersible in aqueous medium or body fluid and leuprolide acetate, an implantor a kit comprising such composition, a method for forming the flowable composition. The present invention is also directed to a biodegradable implant formed in situ, in a patient, to a method of forming a biodegradable implant in situ, in a living patient which includes injecting a flowable composition within the body of a patient and allowing the biocompatible polar aprotic solvent to dissipate to produce a solid biodegradable implant and a method of treating cancer in a patient by administering to the patient in need of such treatment an effective amount of a flowable composition of the present invention or a method of reducing LHRH levels in a patient. |
申请人 |
ATRIX LABORATORIES, INC.;DUNN, RICHARD, L.;GARRETT, JOHN, S.;RAVIVARAPU, HARISH;CHANDRASHEKAR, BHAGYA, L. |
发明人 |
DUNN, RICHARD, L.;GARRETT, JOHN, S.;RAVIVARAPU, HARISH;CHANDRASHEKAR, BHAGYA, L. |