发明名称 Benzylpiperazinyl and piperidinyl ethanone derivatives: dopamine receptor subtype specific ligands
摘要 Disclosed are compounds of the formula: or pharmaceutically acceptable addition salts thereof wherein: Y represents oxygen or sulfur; Z is nitrogen or CH; R1, R2 and R3 independently represent organic or inorganic substituents; R4 and R4' independently represent hydrogen, alkyl or form a ring with the atom to which they are attached; R5 represents hydrogen, alkyl, alkoxy, or alkylthio, and R6 represents hydrogen or alkyl; or R5 and R6 form a ring together with the atoms to which they are attached; and R7, R8, R9, R10, and R11 independently represent hydrogen or alkyl, which compounds are useful for the treatment and/or prevention of neuropsychological disorders including, but not limited to, schizophrenia, mania, dementia, depression, anxiety, compulsive behavior, substance abuse, Parkinson-like motor disorders and motion disorders related to the use of neuroleptic agents.
申请公布号 US2002045626(A1) 申请公布日期 2002.04.18
申请号 US20010975535 申请日期 2001.10.11
申请人 NEUROGEN CORPORATION 发明人 KOVER RENATA XAVIER;TERDJANIAN SILVA;TRAN JENNIFER;THURKAUF ANDREW
分类号 C07D209/08;C07D295/15;C07D401/06;(IPC1-7):A61K31/495;A61K31/445;C07D241/04;C07D211/32 主分类号 C07D209/08
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