发明名称 |
Method for increasing the compressibility of poorly binding powder materials |
摘要 |
A method is described for the direct compression of particles comprising the steps of subjecting a suspension comprising particles of an active material and a compression excipient in a fluid medium to a pressure force to form a suspension of modified particles, removing said modified particles from said fluid medium to form a dried homogenate; and directly compressing said dried homogenate. The method prepares high active-loaded compression forms by direct compressing a mixture of active material with an excipient composition containing a non-ionic hydrophilic polymer, and a polysaccharide. Also described is a direct compression excipient composition comprising polysaccharide and a non-ionic hydrophilic polymer, which excipient may be combined with an aqueous suspension of the difficult-to-compress active, dried and compressed into a form acceptable for purposes including pharmaceutical applications.
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申请公布号 |
US2002044969(A1) |
申请公布日期 |
2002.04.18 |
申请号 |
US20010862269 |
申请日期 |
2001.05.22 |
申请人 |
HARDEN JEROME;GLOVER DUANE |
发明人 |
HARDEN JEROME;GLOVER DUANE |
分类号 |
A61K9/20;(IPC1-7):A61K9/20;B29B9/00 |
主分类号 |
A61K9/20 |
代理机构 |
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