| 发明名称 |
Novel cephalotaxane derivatives and process for their preparation |
| 摘要 |
The present invention concerns a new general process for asymetric hemisynthesis of harringtonines and their analogs, that are alcaloïds used in chimiotherapy. This process comprises direct esterification of a natural cephalotaxine with an acylating compound constituted of a side chain precursor which backbone and fonctionalization are entirely preformed.
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| 申请公布号 |
US2002045750(A1) |
申请公布日期 |
2002.04.18 |
| 申请号 |
US20010817176 |
申请日期 |
2001.03.27 |
| 申请人 |
ROBIN JEAN-PIERRE;BLANCHARD JULIE;CAVOLEAU SYLVIE;CHAUVIAT LUDOVIC;CHARBONNEL SANDRA;DHAL ROBERT;DUJARDIN GILLES;FOURNIER FLORENCE;GILET CHRYSTELLE;GIRODIER LAURENT;MEVELEC LAURENCE;POUTOT SANDRINE;ROUAUD SYLVIE |
发明人 |
ROBIN JEAN-PIERRE;BLANCHARD JULIE;CAVOLEAU SYLVIE;CHAUVIAT LUDOVIC;CHARBONNEL SANDRA;DHAL ROBERT;DUJARDIN GILLES;FOURNIER FLORENCE;GILET CHRYSTELLE;GIRODIER LAURENT;MEVELEC LAURENCE;POUTOT SANDRINE;ROUAUD SYLVIE |
| 分类号 |
A61P35/00;C07C57/13;C07C59/42;C07C59/48;C07C69/732;C07D303/48;C07D305/08;C07D309/08;C07D453/04;C07D491/20;C07D493/10;(IPC1-7):C0749/02;C0745/02 |
主分类号 |
A61P35/00 |
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