METHODS AND COMPOSITIONS FOR NUCLEIC ACID DELIVERY
摘要
The present provides methods and compositions that enable effective delivery of nucleic to desired cells, including to a solid organ such as a mammalian heart. The methods and compositions enable effective gene transfer and subsequent expression to a majority of cells throughout a solid organ such as the heart. Methods and compositions of the invention preferably provide enhanced vascular permeability that enables increased gene transfer to targeted cells, but without significant degradation or injury to endothelial cell layers.
申请公布号
WO0230470(A1)
申请公布日期
2002.04.18
申请号
WO2001US32274
申请日期
2001.10.15
申请人
JOHNS HOPKINS UNIVERSITY;DONAHUE, KEVIN, J.;MARBAN, EDUARDO;NAGATA, KOICHI;LAWRENCE, JOHN, H.
发明人
DONAHUE, KEVIN, J.;MARBAN, EDUARDO;NAGATA, KOICHI;LAWRENCE, JOHN, H.