COMPOUNDS AND METHODS FOR IDENTIFYING COMPOUNDS THAT INTERACT WITH MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN BINDING SITES ON APOLIPOPROTEIN B AND MODULATE LIPID BIOSYNTHESIS

摘要

Methods of identifying compositions which inhibit lipid and lipoprotein secretion are provided using in vitro assays measuring inhibition of the binding of microsomal triglyceride transfer protein to a specific microsomal triglyceride binding site on apolipoprotein B and lipid complexes.