5-MEMBERED HETEROCYCLE DERIVATIVES AND USE THEREOF AS MONOAMINE OXIDASE INHIBITORS

摘要

The invention relates to compounds of general formula (I) which can be used for producing a medicament for inhibiting monoamine oxydases (MAO) and/or for lipidic peroxydation and/or for acting as modulators of sodium channels. The resulting medicament is particularly for use for treating Parkinson's disease, senile dementure, Alzheimer's disease, Huntington's chorea, amytrophic lateral sclerosis, schizophrenia, depression, psychosis, pain and epilepsy. The inventive compounds correspond to general formula (I), wherein Het is a 5-membered heterocycle comprising 2 heteroatoms and is such that general formula (I) corresponds exclusively to one of the following sub-formulae: (I)1, (I)2, (I)3 and (I)4, wherein A represents especially a substituted phenyl or biphenyl radical, B represents especially H or an alkyl radical, X represents especially NH or S, Y represents O or S, n is a whole number from 0 to 6, R<1> and R<2> represent, independently of each other, especially radicals chosen from the following: a hydrogen atom or an alkyl or cycloalkyl radical; and OMEGA represents NR<46>R<47> or OR<48>, R<46> and R<47> representing especially radicals chosen from the following: an atom of hydrogen and an alkyl, cycloalkyl, alkynyl, cyanoalkyl alkoxycarbonyl, aralkoxycarbonyl or (cycloalkyl)oxycarbonyl radical and R<48> representing a hydrogen atom or an alkyl, alkynyl or cyanoylkynyl radical.