N-(4-ARYLOXYPIPERIDIN-1-YLALKYL) CINNAMIC AMIDES AS CCR33 RECEPTOR ANTAGONISTS

摘要

Compounds of formula (I) in free or salt form, where Ar<1> is phenyl substituted by one or more substituents selected from halogen, cyano, nitro, and C1-C8-alkyl optionally substituted by cyano or halogen, Ar<2> is phenyl optionally which is unsubstituted or substituted by one or more substituents selected from halogen, cyano, hydroxy, nitro, C1-C8-alkyl, C1-C8-haloalkyl, C1-C8-alkoxy or C1-C8-alkoxycarbonyl, R<1> is C1-C8-alkyl substituted by hydroxy, C1-C8-alkoxy, acyloxy, -N(R<2>)R<3>, halogen, carboxy, C1-C8-alkoxycarbonyl, phenyl- C1-C8-alkoxycarbonyl, -CON(R<4>)R<5> or by a monovalent cyclic organic group, R<2> and R<3 > are each independently hydrogen or C1-C8-alkyl, or R<2> is hydrogen and R<3> is acyl or SO2R<6>, or R<2> and R<3> together with the nitrogen atom to which they are attached denote a 5- or 6-membered heterocyclic group, R<4> and R<5> are each independently hydrogen, C1-C8-alkyl optionally substituted by hydroxy or phenyl, or phenyl optionally substituted by C1-C8-alkyl, halogen, cyano or C1-C8-alkoxy, or R<4> and R<5> together with the nitrogen atom to which they are attached denote a 5- or 6-membered heterocyclic group, R<6 >is C1-C8-alkyl, C1-C8-haloalkyl, or phenyl optionally substituted by C1-C8-alkyl, and n is 1, 2, 3 or 4. The compounds are useful as pharmaceuticals.