COMPOSITIONS AND METHOD FOR PREVENTING REACTOGENICITY ASSOCIATED WITH ADMINISTRATION OF IMMUNOGENIC LIVE ROTAVIRUS COMPOSITIONS
摘要
<p>The present invention provides compositions for making a medicament and methods for the administration of a vaccine compositions for protection against human rotaviral disease without significant reactogenicity. Human x rhesus reassortant rotavirus compositions were made which when administered during the first 7 to about 10 days of life, provided a composition which was non-reactogenic followed by booster immunizations at 16 to 18 weeks or 14 to 20 weeks, up to 1 year of age. The immune response induced by the initial neonatal administration of the live rotavirus vaccine composition protects the infant from the reactogenicity of the composition when administered as a second vaccine dose at or after 2 months of age. Administration of the immunogenic composition also is expected to ablate or significantly diminish the increase in the excess of intussusception observed 3 to 7 days following administration of the initial dose of rotavirus vaccine at about 2 to 4 months.</p>
申请公布号
WO0154718(A3)
申请公布日期
2002.04.18
申请号
WO2001US02686
申请日期
2001.01.26
申请人
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE DEPARTMENT AND HEALTH AND HUMAN SERVICES;KAPIKIAN, ALBERT;CHANOCK, ROBERT;UDEM, STEPHEN;VESIKARI, TIMO
发明人
KAPIKIAN, ALBERT;CHANOCK, ROBERT;UDEM, STEPHEN;VESIKARI, TIMO