| 发明名称 |
NOVEL METHOD FOR SYNTHESIS OF N-[(S)-1-CARBOXYBUTYL]-(S)-ALANINE ESTERS AND USE IN SYNTHESIS OF PERINDOPRIL |
| 摘要 |
<p>The invention concerns a stereoselective method for industrial synthesis of derivatives of formula (I) wherein: R represents a linear or branched C1-C6 alkyl group, from S-norvalinate ethyl and sodium pyruvate. The invention is useful for the synthesis of perindopril and pharmaceutically acceptable salts thereof.</p> |
| 申请公布号 |
WO0156353(A3) |
申请公布日期 |
2002.04.18 |
| 申请号 |
WO2001FR00959 |
申请日期 |
2001.03.30 |
| 申请人 |
LABORATOIRES SERVIER;SOUVIE, JEAN-CLAUDE |
发明人 |
SOUVIE, JEAN-CLAUDE |
| 分类号 |
C07C227/18;A61P9/00;C07B61/00;C07C22/00;C07C227/32;C07C229/16;C07C229/24;C07D209/34;(IPC1-7):C07C227/32 |
主分类号 |
C07C227/18 |
| 代理机构 |
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