METHOD FOR TREATING CYTOKINE MEDIATED HEPATIC INJURY
摘要
A method of modulating cytokine mediated hepatic injury by administering compound-D SEQ ID NO:1 to a mammal. A concentration of the compound in the range of about 0.5 mg/kg to about 20 mg/kg in a physiologically acceptable formulation blocks a cytokine cascade. A therapeutic method of modulating cytokine mediated acute inflammatory, trauma induced and toxin induced hepatic injury, particularly via tumor necrosis factor modulation, is thus disclosed.
申请公布号
WO0230442(A2)
申请公布日期
2002.04.18
申请号
WO2001US31433
申请日期
2001.10.09
申请人
UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION;ZYMOGENETICS
发明人
OELTGEN, PETER, R.;MCCLAIN, CRAIG, J.;BARVE, SHIRISH;BISHOP, PAUL, D.