发明名称 Statistical processing of gene sequences to determine possible haplotypes and their probability, useful e.g. for identifying genetic origins of complex diseases
摘要 Processing (M1) gene sequences of diploid organisms, in which, for each genotype considered, from a given sample group, the number of possible haplotype pairs (x,y) and the probability of their appearance are predicted, is new. The process comprises determining: (a) those haplotypes, x, that are compatible with g; (b) pairs (x,y) of g-compatible haplotypes from which g can be assembled; and (c) the probability h(g,x) of the haplotype, through a statistical estimation method. Then at least one haplotype pair with a given minimum probability is outputted, stored and/or displayed. Independent claims are also included for the following: (1) computer program (I) for the new method; and (2) apparatus (II) for performing the method.
申请公布号 DE10050361(A1) 申请公布日期 2002.04.18
申请号 DE20001050361 申请日期 2000.10.11
申请人 GENPROFILE AG 发明人
分类号 C12Q1/68;G01N33/48;G06F17/18;G06F19/18;G06F19/22;G06F19/24;(IPC1-7):G01N33/48 主分类号 C12Q1/68
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