Use of amino-substituted imidazo(1,2-a)pyridine, imidazo(1,2-a)pyrimidine and imidazo(1,2-a)pyrazine derivatives as NO synthase inhibitors, e.g. in treatment of migraine and neurodegenerative diseases

摘要

New amino-substituted imidazo(1,2-a)pyridine, -pyrimidine and -pyrazine derivatives (I) and their salts are used for the production of medicaments for NO synthase inhibition. New amino-substituted imidazo(1,2-a)pyridine, -pyrimidine and -pyrazine derivatives of formula (I) and their salts are used for the production of medicaments for NO synthase inhibition: X = CR<4> or N; Y = CR<5>; W = N or NR<8>; R<1> = 1-12C alkyl; 3-8C cycloalkyl; CH2-3-8C cycloalkyl; heterocyclyl; aryl; heteroaryl; 1-8C alkyl-aryl; or 1-8C alkyl-heteroaryl; R<2> = H or C(O)R<9>; R<3> = 1-8C alkyl; 3-8C cycloalkyl; heterocyclyl; aryl; heteroaryl; 1-8C alkyl-3-8C cycloalkyl; 1-8C alkyl-heterocyclyl; 1-8C alkyl-aryl; or 1-8C alkyl-heteroaryl; R<4>-R<7> = H; 1-8C alkyl; 3-8C cycloalkyl; F; Cl; Br; I; CN; NO2; NH2; C(O)R<9>; CO2H; CO2R<10>; OH; or OR<11>; or R<4>+R<5> or R<5>+R<6> or R<6>+R<7> = 4-membered, saturated or unsaturated hydrocarbyl bridge (optionally containing 1-3 N, O and/or S atoms) and the other R<4>-R<7> is H; R<8> = C(O)R<5>; R<9> = 1-8C alkyl; 3-8C cycloalkyl; CH2-3-8C cycloalkyl; heterocyclyl; aryl; heteroaryl; 1-8C alkyl-aryl; or 1-8C alkyl-heteroaryl; R<10>+R<11> = 1-8C alkyl; 3-8C cycloalkyl; CH2-3-8C cycloalkyl; aryl; or 1-8C alkyl-aryl; alkyl, cycloalkyl and heterocyclyl are optionally unsaturated and alkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl are optionally mono- or poly-substituted; compounds (I) are excluded when X = Y = N.