| 发明名称 |
METHOD FOR MODIFYING A PROTEIN STRUCTURE |
| 摘要 |
The present invention relates to stabilisation of proteins. A theoretical basis for new protein engineering strategies is presented, based on defining rules for strong hydrogen bonds in proteins. In the present invnetion pairs of carboxylic acid side chains are used to stabilise proteins, or to form pH-dependent molecular switches.
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| 申请公布号 |
WO0230953(A1) |
申请公布日期 |
2002.04.18 |
| 申请号 |
WO2001FI00884 |
申请日期 |
2001.10.12 |
| 申请人 |
VALTION TEKNILLINEN TUTKIMUSKESKUS;WOHLFAHRT, GERD;BOER, HARRY;KOIVULA, ANU |
发明人 |
WOHLFAHRT, GERD;BOER, HARRY;KOIVULA, ANU |
| 分类号 |
C12N15/09;C07K1/00;C07K1/107;C07K16/00;G11C13/02;(IPC1-7):C07K1/00;G01N33/68 |
主分类号 |
C12N15/09 |
| 代理机构 |
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