The present invention relates to novel Death Domain Containing Receptor-4 (DR4) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR4 proteins. DR4 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR4 activity and methods for using DR4 polynucleotides and polypeptides.
申请公布号
WO0067793(A9)
申请公布日期
2002.04.18
申请号
WO2000US12163
申请日期
2000.05.05
申请人
HUMAN GENOME SCIENCES, INC.;THE REGENTS OF THE UNIVERSITY OF MICHIGAN;NI, JIAN;ROSEN, CRAIG, A.;PAN, JAMES, G.;GENTZ, REINER, L.;DIXIT, VISHVA, M.
发明人
NI, JIAN;ROSEN, CRAIG, A.;PAN, JAMES, G.;GENTZ, REINER, L.;DIXIT, VISHVA, M.