6-Alkenyl-, 6-alkynyl- and 6-epoxyepothilone derivatives, process of their preparation and use in pharmaceutical preparations

摘要

This invention describes the new 6-alkenyl- and 6-alkinyl- epothilone derivatives of general formula (I) in which R<1a>, R<1b>, R<2a>, R<3a>, R<3b>, R<4>, R<5>, R<6>, R<7>, A, Y, D, E, G, Y and Z have the meanings that are indicated in the description. The new compounds interact with tubulin by stabilizing microtubuli that are formed. They are able to influence the cell-splitting in a phase-specific manner and thus find use in treating diseases or conditions associated with the need for cell growth, division and/or proliferation. Thus the compounds are suitable for treating malignant tumors, for example, ovarian, stomach, colon, adeno-, breast, lung, head and neck carcinomas, malignant melanoma, acute lymphocytic and myelocytic leukemia. In addition, they are suitable for anti-angiogenesis therapy as well as for treatment of chronic inflammatory diseases (such as psoriasis, arthritis). Methods of use and preparation of the compounds are also described.