发明名称 |
METHODS AND COMPOSITIONS FOR ENGINEERING OF ATTENUATED VACCINES |
摘要 |
<p>This invention provides attenuated vaccines, and methods of obtaining attenuated vaccines. The vaccines of the invention include recombinant viral, bacterial, parasite, and other organisms that are evolved to exhibit increased attenuation without loss of effectiveness as a vaccine. The methods involve the creation of libraries of recombinant nucleic acids (e.g., whole or partial genomes, or particular nucleic acids) which are introduced into the vaccine viruses or other organisms, followed by screening and/or selection for those viruses or organisms that are attenuated.</p> |
申请公布号 |
EP1196552(A2) |
申请公布日期 |
2002.04.17 |
申请号 |
EP20000944760 |
申请日期 |
2000.06.20 |
申请人 |
MAXYGEN, INC. |
发明人 |
PUNNONEN, JUHA;HOWARD, RUSSELL;STEMMER, WILLEM, P., C.;DELCARDAYRE, STEPHEN;APT, DORIS |
分类号 |
C12N15/09;A61K39/00;A61K39/12;A61K39/145;A61K39/155;A61K39/21;A61K39/255;A61K39/265;A61K39/29;A61K39/295;A61P31/00;C12N7/04;C12Q1/68;(IPC1-7):C12N15/00;C12N1/36 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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