MEDICINAL COMPOSITIONS FOR PREVENTING OR TREATING DIARRHEA

摘要

Provided is a pharmaceutical composition for the prevention or treatment of a diarrhea, which comprises as an active ingredient, siastatin B or a siastatin B derivative having a beta -glucuronidase inhibitory activity. Siastatin B or the siastatin B derivative is useful as a drug for the prevention or treatment of a diarrhea, which is capable of ameliorating the diarrhea disorders as induced as a side effect when a cancer-bearing patient received the administration of an anticancer chemotherapeutic agent, particularly an anticancer camptothecin derivative acting as a topoisomerase I inhibitor. This composition is effective to prevent or treat such diarrhea as induced by the administration of an anticancer camptothecin derivative to the cancer-bearing patient.