| 摘要 |
PURPOSE: Provided is a water-insoluble crosslinked amide derivative of hyaluronic acid, which can be used for a film for preventing adhesion after an operation, a wrinkle curing agent, and an auxiliary for a plastic surgery. CONSTITUTION: The crosslinked amide derivative of hyaluronic acid is produced by crosslinking the hyaluronic acid or cation salts thereof with a polymer or an oligomer having at least two amine groups by an amidation in the presence of an activator of a carboxyl group, wherein the polymer or the oligomer is selected from the group consisting of chitosan, chitosan derivatives, deacetylated hyaluronic acid or cation salts thereof, peptide having at least two reactive amine groups, and protein. The ratio of carboxyl group of the hyaluronic acid or the cation salts thereof and the amine groups of the polymer or the oligomer is 1:0.01-100.
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