发明名称 |
PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE 2- 6-(HYDROXYMETHYL)-1,3-DIOXAN-4-YL]ACETIC ACID DERIVATIVES |
摘要 |
This invention provides a process for producing optically active 2-Ä6-(hydroxymethyl)-1,3-dioxan-4-ylÜacetic acid derivatives, which are of value as intermediates of drugs, from inexpensive starting materials without using any special equipment such as that required for super-low temperature reactions. <??>A process for producing optically active 2-Ä6-(hydroxymethyl)-1,3-dioxan-4-ylÜacetic acid derivatives which comprises reacting an acetic acid derivative at a temperature of not less than -30 DEG C with an enolate prepared by permitting either a base or a metal having a valency of 0 to act on the derivative to produce a hydroxyoxohexanoic acid derivative, reducing this compound with the aid of a strain of microorganism to provide a halomethyldioxanylacetic acid derivative, treating this compound with an acetalizing agent in the presence of an acid catalyst to provide a halomethyldioxanylacetic acid derivative, reacted with an acyloxylating agent to provide a acyloxymethyldioxanylacetic acid derivative, and subjecting this compound to solvolysis in the presence of a base. |
申请公布号 |
EP1024139(A4) |
申请公布日期 |
2002.04.17 |
申请号 |
EP19990935066 |
申请日期 |
1999.08.05 |
申请人 |
KANEKA CORPORATION |
发明人 |
KIZAKI, NORIYUKI;YAMADA, YUKIO;YASOHARA, YOSHIHIKO;NISHIYAMA, AKIRA;MIYAZAKI, MAKOTO;MITSUDA, MASARU;KONDO, TAKESHI;UEYAMA, NOBORU;INOUE, KENJI |
分类号 |
C07C67/343;C07C253/30;C07C255/21;C07D319/06;C12P7/62 |
主分类号 |
C07C67/343 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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