发明名称 BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS MODULATORS OF THE GABAA RECEPTOR COMPLEX
摘要 The present patent application discloses compounds having the formula (see formula I) or a pharmaceutically acceptable salt thereof or an oxide thereof wherein R3 is (see formula II) wherein A, B and D each is CH, or one or two of A, B and D is N and the others a re CH;~ R11 is phenyl, benzimidazolyl, or monocyclic heteroaryl all of which may be substituted one or more times with substituents selected from alkyl, halogen , CF3, amino, nitro, cyano, acylamino, alkoxy, acyl, phenyl, and monocyclic heteroaryl, and one of R6 and R7 is hydrogen and the other is pyrrolyl which may be substituted one or more times with substituents selected from halohen, alkyl , phenyl, and alkoxy. The compounds are useful for the treartment of various central nervous syst em disorders such as epilepsy and other convulsive disorders, anxiety, sleep disorders and memory disorders.
申请公布号 CA2217601(C) 申请公布日期 2002.04.16
申请号 CA19962217601 申请日期 1996.04.19
申请人 NEUROSEARCH A/S;MEIJI SEIKA KAISHA, LTD. 发明人 TEUBER, LENE;WATJEN, FRANK
分类号 C07D401/14;A61K31/415;A61K31/4184;A61K31/44;A61K31/4427;A61K31/443;A61K31/4439;A61K31/501;A61K31/505;A61K31/506;A61P25/00;A61P25/08;A61P25/20;A61P25/22;A61P25/28;A61P43/00;C07D235/06;C07D401/10;C07D403/10;C07D403/14;C07D405/10;C07D405/14;C07D409/10;C07D413/14;C07D417/10;C07D417/14;C07D521/00;(IPC1-7):C07D401/14;C07D409/14;A61K31/495 主分类号 C07D401/14
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