| 摘要 |
PROBLEM TO BE SOLVED: To provide a compound having activities for inhibiting the production of interleukin-6(IL-6), and thereby to use the compound as a therapeutic agent of a disease accompanied with abnormal production of the IL-6, i.e., immune disease such as rheumatics and neoplastic disease such as multiple myeloma. SOLUTION: This compound is a 4-(3-indolyl)imidazole derivative represented by formula (I) [wherein, R1 is a group of formula (II) (wherein, R3 and R4 are same or different and each a hydrogen atom, a halogen atom, a 1-6C alkyl group, a 1-6C alkoxy group, a 1-3C perfluoroalkyl group or a cyano group), a group of formula (III) (wherein R5 is a halogen atom) or a 3-6C cycloalkyl group; R2 is a pyridyl group or a group of formula (IV) (wherein, R6 is a 1-6C alkylthio group, a 1-6C alkylsulfinyl group, a 2-8C dialkylamino group, a 1-3C perfluoroalkyl group, a 2-phenylethyl group or a 2-phenylethenyl group)], or a pharmaceutically acceptable salt thereof.
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