发明名称 |
SCREENING METHOD FOR IDENTIFYING LIGANDS FOR TARGET PROTEINS |
摘要 |
A novel method for screening chemical compounds (test ligands) for potential pharmaceutical effectiveness is provided. The disclosed method identifies possible therapeutic test ligands by placing them in the presence of target proteins and determining their ability to increase or decrease the ratio of folded target protein to unfolded target protein. The present methods do not require that biochemical function of the target protein be known, nor that any other ligands be previously identified.
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申请公布号 |
CA2184195(C) |
申请公布日期 |
2002.04.16 |
申请号 |
CA19962184195 |
申请日期 |
1996.08.26 |
申请人 |
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发明人 |
PAKULA, ANDREW;BOWIE, JAMES |
分类号 |
G01N33/53;A61K38/16;A61K38/43;A61K45/00;C12Q1/37;G01N33/15;G01N33/566;G01N33/569;G01N33/573;G01N33/68;G01N33/72;(IPC1-7):G01N33/53 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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