ESTABLISHED RETINAL NERVE CELL

摘要

PROBLEM TO BE SOLVED: To obtain a retinal nerve cell strain usable for developing a useful medicine for retinal diseases. SOLUTION: This retina-derived nerve cell strain capable of maintaining a passage is derived from a transgenic animal to which a temperature-sensitive mutant SV40 large-T antigen gene is transferred, especially preferably a transgenic rat and can establish, for example, a retinal gangliocyte, amacrine cell, horizontal cell, visual cell. The obtained established retina-derived nerve cell is useful for screening a medicine acting on ophthalmologic diseases (medicine for age-related macular degeneration, retinitis pigmentosa, glaucoma, diabetic retinopathy, or the like).