BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS MODULATORS OF THE GABAA RECEPTOR COMPLEX

摘要

The present patent application discloses compounds having the formula or a pharmaceutically acceptable salt thereof or an oxide thereof wherein R3 is wherein A, B and D each is CH, or one or two of A, B and D is N and the others a re CH; R11 is phenyl, benzimidazolyl, or monocyclic heteroaryl, all of which may be substituted one or more times with substituents selected from alkyl, alkoxy, halogen, CF3, amino, nitro, cyano, acylamino, acyl, phenyl and monocyclic heteroary l; one of R6 and R7 is hydrogen and the other is -CR'=NOR", wherein R' and R" each independently are hydrogen, alkyl, alkenyl, alkynyl or phenyl. The compounds are useful for the treartment of various central nervous syst em disorders such as epilepsy and other convulsive disorders, anxiety, sleep disorders and memory disorders.