Production of fluorinated benzaldehyde compounds, used as intermediates for production of pharmaceuticals, involves hydrogenation of corresponding benzoyl chloride using supported palladium catalyst and moderator

摘要

A method for the production of fluorinated benzaldehydes (I) involves hydrogenation of the corresponding fluorinated benzoyl chloride with hydrogen in presence of a supported palladium catalyst and a catalyst moderator. A method for the production of fluorine-containing benzaldehydes of formula (I), in which [Image] n : 1 or 2; R1-R3H, fluorine, chlorine, bromine, or 1-6C alkyl, fluoroalkyl, fluoroalkoxy or fluoroalkylthio, with at least one of these groups being fluorine or a fluorinated group and not more than two of these groups being bromine, 1-6C fluoroalkoxy and/or 1-6C fluoroalkylthio , involves reacting the corresponding aromatic acid chloride (II) (with COCl instead of CHO in formula (I)) with hydrogen in presence of a supported palladium catalyst and a catalyst moderator.